Filmmaker Kunal Kohli is back with another review and this time it is for Imtiaz Ali's Main Vaapas Aaunga , which had a surprising change at the box office and qualified as a sleeper hit. From audiences to the fraternity, everyone has been raving about all the performances and how well made the film is. Kunal Kohli too applauded it, calling Main Vaapas Aaunga Imtiaz Ali's finest work. What's Happening Kunal Kohli shared a video on Instagram and said, "I just saw Main Vaapas Aaunga and the film has left a huge impact on me. My bua and dad used to often speak about Partition and a lot of it was in this film. They would talk about the horrors and after-effects of it. And of course, there were relatives who never spoke about it, which is also shown in the film. The love story is truly so innocent, pure and beautiful. This is Imtiaz's finest work. So beautifully he has shown the love, the news back then - the news was so slow, things travelled so slowly. Whereas...
Scientists in the United States have discovered a biological "switch" that could play a vital role in weight loss. The research highlights the importance of the amino acid cysteine, showing that its depletion can trigger the conversion of white fat, which stores energy, into brown fat, which burns calories and produces heat.
This process, the researchers explained, helps make the body's metabolic functions more efficient, offering a new way to understand how calorie reduction leads to weight loss. While earlier studies suggested cysteine might influence fat activity, this is the first direct evidence of its key role.
According to the team, keeping cysteine levels in check may serve as a new pathway for developing therapies to fight obesity and promote healthier metabolism.
"In addition to the dramatic weight loss and increase in fat burning resulting from the removal of cysteine, the amino acid is also central to redox balance and redox pathways in biology," said Dr Stadler, who directs the Oxidative Stress and Disease laboratory at Pennington Biomedical. "These results suggest future weight management strategies that might not rely exclusively on reducing caloric intake."
The research is based on results from trials involving both human participants and animal models. For the human trials, researchers examined fat tissue samples taken from trial participants who had actively restricted calorie intake over a year. When examining the fat tissue samples, they looked for changes in the thousands of metabolites, which are compounds formed when the body breaks down food and stores energy. The exploration of these metabolites indicated a reduced level of cysteine.
"Reverse translation of a human caloric restriction trial identified a new player in energy metabolism," said Dr Ravussin, who holds the Douglas L Gordon Chair in Diabetes and Metabolism at Pennington Biomedical and oversees its Human Translation Physiology Lab. "Systemic cysteine depletion in mice causes weight loss with increased fat utilisation and browning of adipocytes."
The study has been featured in Nature Metabolism, a leading academic journal.
from NDTV News- Special https://ift.tt/dPOZHch
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